Contaminated abdominal wall defects are always a challenge to repair. Several techniques are described in the literature to variable outcomes. We report a complicated case of abdominal wall abscess secondary to perforated Meckel’s diverticulum in an obese lady with a recurrent large ventral hernia. Such a case was not previously reported in the literature. Abdominal wall repair was performed using a biosynthetic (STRATTICE™, Allergan) mesh bridge and negative pressure wound therapy.