In 2005, Cottin et al., put forth a term, Combined Pulmonary Fibrosis and Emphysema (CPFE) which is a rare respiratory disorder and is characterized by exertional dyspnoea, upper-lobe emphysema and lower-lobe fibrosis, preserved lung volume and severely diminished capacity of gas exchange.[1][2] The main etiologies behind CPFE are heavy smoking history, hypoxemia, unexpected subnormal lung volumes and severe reduction of carbon monoxide transfer. Highresolution CT (HRCT) is the mainstream diagnostic parameter for CPFE. Apart from HRCT, spirometry values are also used to assess the severity of the disease.[4] Treatment options include symptomatic therapy as there is no specific treatment available till date, and also includes smoking cessation and oxygen therapy.[3] This case series involves 3 cases of CPFE with different symptoms and treatment has been given accordingly.[8]

Keywords : Combined Pulmonary Fibrosis and Emphysema (CPFE), Hypoxemia, HRCT, Spirometry.