 Introduction Laryngopharyngeal reflux is a condition in which there is backward flow of stomach content to the larynx and pharynx and its contact with upper aerodigestive tract.  Aim This study is aimed to determine whether treatment with alkaline water and isotonic saline gargles with standard reflux precautions only can improve symptoms of laryngopharyngeal reflux compared with proton pump inhibitors with standard reflux precautions.  Materials and method It is a prospective study conducted on sample size of 120. Patients were diagnosed with LPR using reflux symptom index. After four weeks of treatment RSI was studied again to see improvements. A 6- point reduction in the RSI score was considered to be significant.  Results Out of 60 treated with proton pump inhibitors, 45 (75%) were responders and out of 60 treated with alkaline water and isotonic saline gargles, 39 (65%) were responding to the treatment.  Conclusion It was found that treatment with alkaline water and isotonic saline gargles was significantly effective but not more than proton pump inhibitors. Hence for long term treatment, alkaline water and isotonic saline gargles would be a better alternative.

Keywords : Laryngopharyngeal Reflux, Proton Pump Inhibitors, Reflux Symptom Index, Alkaline Water, Isotonic Saline Gargles.