Many challenges affect the quality of higher education in Palestine, which requires acting wisely to figure out these challenges and eliminate them in order to improve the quality of higher education through the development of many different and new experiences, systems and methods to improve the quality of higher education institutions. Thus, solutions and alternatives to the current problems and obstacles in similar circumstances have been proposed in order to identify the indicators that influence the quality of higher education institutions in Palestine and identify the different ways to develop these institutions and ensure access to the desired results. In the light of the foregoing, Palestinian higher education institutions have played an important role in supporting the Palestinian and Arab labor market over the past decades and till now with qualified and trained individuals who contribute directly to the overall development of Palestine and the Arab world. However, they suffer from challenges and difficulties that prevent the application of quality. Thus, this paper aims at identifying the obstacles to the application of total quality in the Palestinian higher education institutions, in addition to the role played by the Accreditation and Quality Commission in the Ministry of Education and Higher Education to overcome these obstacles.