 Background: Pseudoexfoliative Syndrome (PEX) and Sudden Cardiac Death (SCD) increase with age. Tp-e (T peak- end interval)and cTp-e (Corrected Tp-e) intervals are recently accepted as predictors of SCD.  Objectives: Our study aimed to investigate the Tp-e, cTp-e intervals in both patients with PEX and non-PEX.  Materials and Methods: The study group consisted of forty-two patients who were admitted to the outpatient clinic of ophthalmology between December-2018 and May-2019 and diagnosed as PEX in the ophthalmologic examination. Forty-three patients with non-PEX, systemic examinations, and routine blood tests were normal, included in the study. The study and control group were included in the treadmill exercise test (TET) according to Bruce Protocol.  Results: In the study group, there was a statistically significant difference between the basal cTp-e interval value and the third-minute recovery cTp-e interval value, whereas in the control group there was no statistically significant difference between the basal cTp-e interval value and the third-minute recovery cTp-e value ( in the study group, basal cTp-e = 85.09 ± 5.14 ms vs third-minute recovery cTp-e = 87.37 ± 3.81 ms, t = 3.07 and p < 0.01, in the control group, baseline cTp-e = 63.65 ± 5.07 ms vs third-minute recovery cTp-e = 63.59 +/- 2.77, t = 0.087 and p = 0.93). There were moderate positive correlations between HRR-I (Heart Rate Recovery Index)values and cTp-eR-I (Corrected Tp-e Recovery Index) values in each recovery stage of the effort test in both the study and control group.  Conclusion: These findings suggest that the risk of ventricular arrhythmias is higher in patients with PEX than in patients with non-PEX and that autonomic function in PEX patients is more impaired than non-PEX patients.

Keywords : Exfoliation Syndrome, Risk, Exercise Test, Sudden Cardiac Death.