Bacterial diseases are becoming a more severe problem around the world. Treatment of multidrugresistant pathogens has become a major concern in the present world. Bacterial efflux pumps are present in all microorganisms and play a key role in both innate and acquired bacterial drug resistance. Therefore, discovering small molecule efflux pump inhibitors (EPIs) that are capable of restoring antibiotic effectiveness is a hot topic in the scientific world. Seeking new EPIs has taken a lot of effort over the past two decades. None of them, however, has yet to be approved for medicinal use. To introduce these inhibitors for escalating the responsiveness of bacterial pathogens to antibiotics, we should have proper knowledge of drug detection and the mechanism of efflux pumps. This review of EPIs is a good place to start looking for new anti-bacterial drugs that are safe

Keywords : Efflux Mechanisms, Efflux Pump Inhibitor (EPI), Antibiotic Resistance, Multidrug Resistant (MDR), Bacteria.