The inductively coupled plasma mass spectrometry (ICP-MS) owns the necessary ability to run elemental ultra-trace detection, as well as to elucidate temporally overlapping chromatographic peaks. In geochemistry, environmental and clinical studies of trace elements, ICP-MS plays a very important role in all its variants. In its versatility, ICP-MS has increased the scope of research as well as, together with new and improved methodologies for sample preparation, has changed the direction of interest and filled knowledge gaps in elemental and isotopic characterization. ICP-MS is the best detector with low detection limits, mass selectivity, large dynamic ranges, high sensitivities, isotope ratio capacities, and high throughput in traditional speciation analysis. With the aid of ICP-MS, the struggle to look for an outstanding form of quantification, such as drugs and proteomics, has come substantially close to an end. In short, ICP-MS will play a more and more significant role in pharmaceutical, biomedical, soil, clinical, forensic, and food research.

Keywords : ICP-MS; Detection; Sample Preparation