Transdermal drug delivery system(TDDS) is self-contained, discrete dosage form in which drug stick to the body surface and delivers the drug, across the skin at controlled rate into the blood stream. TDDS has been a great field of interest in recent times. Many drugs which can be injected directly into the blood stream via skin have been formulated by TDDS. Transdermal drug delivery system (TDDS) provides a means to sustain drug release as well as reduce the intensity of action and thus reduce the side effects associated with its oral therapy. However, a detail study of transdermal delivery provides a lot of advantages compare to oral intake or hypodermic injection. Firstly dermal layer dermal layers provides the drug a shorter route to the bloodstream than gastrointestinal tract does. In the given review the main point of focus is to explore the commercial advantages and the strategic developed transdermal patches.