Diabetes Mellitus is a chronic disease that occurs because the pancreas doesn’t produce enough insulin or cannot effectively use the insulin it produces. Knowledge is a factor that facilitates adherence. The purpose of this study was to determine the effect of the level of knowledge on adherence to medication use in patients with type 2 diabetes mellitus. This Cross Sectional Prospective study was conducted from December 2020 to March 2021 at the Apotek Program Rujuk Balik BPJS dr. Misbah 2 Pekanbaru with 98 respondents as a subject. The research instrument used was a knowledge questionnaire containing 16 questions about Diabetes Mellitus and the Pill Count Method to assess adherence. The results showed that there was a relationship between education level and knowledge and there was a relationship between gender, age and the number of drug combinations with compliance. The results of the chi square test of knowledge with compliance obtained a significance of 0.032 (p <0.05). So it can be concluded that knowledge has a relationship with drug use compliance in type 2 Diabetes Mellitus patients.

Keywords : Type 2 Diabetes Mellitus, Knowledge, Adherence, Rujuk Balik Programme.