The present research work was done with traditional medicinal plants. The plant materials such as Terminalia bellerica, Withania somnifera, Madhuca longifolia and Sygyzium cumini was selected based on its potent antimicrobial activity. The best combination of the selected plants was evaluated for their antimicrobial activity. The extract showed significant activity towards the test organisms. The results recommended the use of selected plants at their best combination as a substitute to synthetic agents that can effectively prevent the microbial infestation.

Keywords : Antimicrobial Activity, Cross Infection, Medicinal Plant.