Malaria is the cause of mortality and morbidity around the world especially in sub-Saharan Africa. Gambella is one of the endemic places of malaria. The present study has been conducted to assess malaria infection rate in Gambella University and factors that favor the transmission. Retrospective study was conducted by using recorded patient registration book from the university’s clinic and descriptive survey was carried out through questionnaires that participated 385 respondent students. Within in 2019 academic year, 1,189 (61.5%) malaria cases has been reported and 99.24% of the infection was caused by P. falciparum. Repeated infection is also common with in the students. The presence of suitable environmental conditions like swamps and stagnant water has been confirmed by 94% of the students. This study also discovered less use of ITN and long sleeve closes by the students to protect their body parts from the mosquito bite. Generally there is a high rate of malaria infection in the university. The environmental conditions also create a suitable reproduction site for mosquitos which increases the infection rate.

Keywords : Malaria, Gambella University, Infection.