Regularly a diagnostic aid, ultrasound, the emerging hopeful tool for administering drug to the patient in periodontal diseases and for the treatment of genetic disease. The ultrasonography releases bio-effects creating in production of heat to the tissues, force causes on the layers of the tissue, and formation of cavity in the organ, that has been useful for therapeutic purposes. Ultrasound cavitation, becomes better by sending micro bubbles. Many new drug delivery systems have come for intrapocket delivery of drugs i.e., injectable drug delivery systems, strips and compacts, Nano drug delivery systems, gene delivery using bubble liposomes for periodontal therapy. Sonoporation is a new advanced technique to release the drug from drug delivery systems in treating periodontal diseases.

Keywords : Ultrasound, Sonoporation, Gene therapy, Drug delivery.