The study investigated Class Size and Teachers’ Classroom Control in Public Secondary Schools in Uyo Education Committee (LEC) of Akwa Ibom State. Two research questions were raised and the two research hypotheses were formulated to guide the study. The design of the study was ex-post facto. The population comprised 4937 SSII students in the fourteen public secondary schools in Uyo LEC. Stratified random sampling technique was used to select the sample size of 500 students. A researcher-developed instrument, “Class Size and Teachers’ Classroom Control Questionnaire” (CSTCCQ) validated by experts, were used to gather the data. The reliability co-efficient of the instrument was determined using the Cronbach Alpha. The reliability index of 0.86 was obtained. The mean and standard deviation were used to answer the research questions while the independent ttest was used to test the hypotheses at .05 alpha levels. The findings of the study reveal that there is significant difference in teachers’ engagement of students during class activities and supervision based on class size. The study therefore concluded that a school should have a class size that the teachers should be able to manage while being cost effective since the size of a class significantly relates to teachers’ classroom control in public secondary school in Uyo Local Education Committee of Akwa Ibom State. It was recommended that all the teachers in Akwa Ibom State should be trained and re-trained in classroom management.