Nasopharyngeal mass is not an uncommon entity. Many types of masses including some rare ones have been mentioned in literatures. Because of the diversity of the cell types in the nasopharynx varied lesions may occur which might prove to be diagnostically challenging. Aim and Objectives: To evaluate the clinicopathological spectrum of nasopharyngeal masses. MATERIALS AND METHOD: A prospective study was carried out in the Department of Pathology, Assam Medical College from September 2009 to August 2010. All nasopharyngeal masses were studied histopathologically with routine H&E stain and Immunohistochemistry was done as and when required. The bio-data, clinical profiles and histopathological diagnoses were analyzed. RESULTS: The study comprised of 50 cases of nasopharyngeal masses. Age of the patients ranged from 8.5 years to 63 years with 36 males and 14 females. of the total 50 cases, 25 cases (50 %) are non neoplastic and the rest 25 cases (50 %) are neoplastic. Among the neoplastic cases malignant masses are more common in the nasopharynx than the benign masses comprising 16 cases (64 %) and 9 cases (36 %) of the neoplastic lesions respectively. Nasopharyngeal carcinoma is the commonest neoplastic lesion as well as the commonest malignant lesion. Among the benign lesion nasopharyngeal angiofibroma was the most common. Adenoids constituted the commonest non neoplastic masses. Nasal obstruction was the most common presenting symptom. CONCLUSION: Nasopharynx can be a site for a variety of lesions and can occur in all age groups. Among the neoplastic masses majority are malignant in nature. Histopathology along with clinical correlation plays an important role in the diagnosis and management of such masses.

Keywords : Nasopharynx; Northeast India; Clinicopathological.