- Collagens are a family of extracellular matrix that helps tissues and organs retain their structural integrity. In mammals, it accounts for about 30% of all proteins and forms a building block of body structure. It is predominantly present in the skin, blood vessels, tendons, cartilages, bone, teeth, and cornea. It plays an important role in the healing of wounds and fractures. Excessive collagen in the body leads to fibrosis of various organs. There are certain diseases related to collagen such as Ehlers- danlos syndrome, Osteogenesis imperfecta, Alport syndrome, Scurvy, Oral submucous fibrosis, Marfan’s syndrome. Collagen's function in health and disease is discussed in this review article

Keywords : Collagen; Extracellular Matrix; Structure; Fibroblast.