 Background : ketamine administered at a dose of 10 mg before the injection of propofol reduces pain from the injection of propofol. The optimal dose of lidocaine is assumed to prevent pain from the injection of propofol. The aim of this study was to assess the comparison of the scale of pain from injection of propofol preceded by lidocaine and ketamine injections in general anesthesia.  Method : Experimental analytical research with a double- blind randomized control trial design using a sample of 50 elective surgical patients. Patients were divided into two groups, treatment group (n = 25) given lidocaine and control group (n = 32) given ketamine. Pain scores were asked every 5-second interval and the highest pain scale was recorded as the research data. If the patient says no, the pain scale is 0. The measuring instrument used in the study was VAS. The data were analyzed using SPSS.  Results : In this study it was found that in the ketamine treatment group, 13 people (52%) did not feel pain, 8 people (32%) felt mild pain, 3 people (12%) felt moderate pain, and 1 person (4%) felt severe pain. In the lidocaine group, 19 people (76%) did not feel pain, 8 people (20%) felt mild pain, 1 person felt moderate pain (4%) and no one felt severe pain. Severe degree of pain was not occurred in the lidocaine group, whereas in the ketamine group, there were still samples that experienced a severe degree of pain after injection of propofol. Based on the difference test conducted in the Mann-Whiteny test it was found that there was no difference in the degree of pain from the injection of propofol whether preceded by an injection of lidocaine or ketamine.  Conclusion : There was no difference in the degree of pain from injection of propofol preceded by lidocaine and ketamine injections.

Keywords : Ketamine, Lidocaine, Visual Analogue Scale (VAS).