Corona VIrus Disease 2019 (COVID-19) is caused by the novel coronavirus (SARS-CoV-2).It affects mainly the respiratory system and hampers the functioning of the lungs and other vital organs. This led to significant morbidity and mortality. During the initial phase of the COVID-19 pandemic, there was no substantial clinically approved line of treatment was available for COVID-19 disease throughout the world. To combat the rapid transmission of the virus in humans; the basic measure adopted like the practice of social distancing, wearing face masks, frequent hand washing, using sanitizers, avoiding crowded places and isolation of COVID positive patients becomes popular all over the world.Thus, lockdown measures were imposed to break the chain of virus transmission by the government of various countries. But to which extent the lockdown can be imposed as it is not a permanent solution to fight against COVID-19. In the past, we have observed that vaccination plays an important role in the prevention and eradication of many serious communicable diseases. Vaccination reduces the risk of complication and mortality in case of further infection. Mass-scale vaccination creates herd immunity in the population. Presently, there are many COVID-19 vaccines available across the world. As we know, the third wave of COVID-19 is about to hit our country, India. The Government is deliberately making an effort by mass-scale immunization campaigns for every individual, even at the rural level. The hesitancy in vaccine among individual is affected by a combination of few factors involving role of media and communication, religious beliefs, trust, role of health professionals and economical. People in the community are still reluctant/resistant or hesitant in accepting COVID-19 vaccination that affects herd immunity & likewise, we cannot fight against this raging pandemic. Thus, this review emphasizes the COVID-19 vaccination hesitancy, assesses its possible factors and various strategies to enhance acceptance of vaccination in the community.

Keywords : COVID-19, Vaccine Hesitancy, Vaccination Hesitancy, Vaccination Acceptance, Vaccination Refusal, Vaccination Uptake