Dalbergia sissoo, is extensively make use of the treatment of many diseases in different parts of India. In the current investigation, cancer preventive efficacy of D. sissoo was evaluated on 7, 12-dimethyl benz (a) anthracene (DMBA) treated skin carcinogenesis in Swiss albino mice. Single topical treatment of DMBA followed 2 weeks later through repeated application of croton oil and continued till the completion of the experiment. Group I (vehicle treated control); group II Carcinogen treated control; Group III Dalbergia sissoo leaf chloroform extract control and group IV Leaf chloroform extract of Dalbergia sissoo 200, 400 and 600 mg/kg, 7 days before and after that for 16 weeks along with croton oil treatment

Keywords : Dalbergia sissoo Leaves, Chloroform Extract, Carcinogen