Rosuvastatin calcium tablets are mainly five brands obtainable that is a synthetic compound which decreases the number of lipid portion which is placed as a hypercholesterolemia treatment. The major purpose of this study is to measure the stability of different brands of Rosuvastatin calcium on the stress condition. Degradation system is a procedure that includes the degradation of drug particles and drug ingredients at specific conditions. Those are generated into degradation products which can be studied to evaluate the quality and efficacy of the drug formulation. There are some guidelines of the International Conference on Harmonization (ICH) with some parameters which cause the degradation of a drug product includes heat test, UV light test, time test for 15 days, acidic pH test, basic pH test. In this study, using an ultraviolet UV spectroscopic system was exhibited for the exploration of the drug absorbance in the whole degradation products. The standard solution of the samples was prepared with water as a solvent to produce a solution containing Rosuvastatin calcium (10mg). Then similarly different brands of drugs were dissolved in water and various dilutions were made which measured the absorbance of Rosuvastatin calcium (10mg) based on an ultraviolet wavelength of 232 nm. The analysis of absorbance of sample preparation calculated at 232 nm against the ratio of blank sample and this study determined through comparing with the evaluation of absorbance data of different brands. The research content result as well as the limit of assays not less than 95% and not more than 105% of the labeled amount the limit of the assay which is specified by USP. It was the final decision that under-five procedures, the entire five brands were degraded in every stress conditions

Keywords : Degradation study, Rosuvastatin calcium, UV Spectrophotometer, Storage Condition.