Oral aspirin treatment in the secondary prevention of heart and cerebral vascular disease is well known. However, oral administration can cause damage to the gastrointestinal mucosa until bleeding occurs. These problems can be overcome by development of transdermal drug delivery system. The objective of this study was to develop and evaluate the transdermal patches of aspirin.Giving aspirin by transdermal patch with matrix type to increase the antithrombotic efficiency of aspirin. The principle of making transdermal patches by solvent evaporation with aspirin and polymer such as Eudragit RS 100, Eudragit RL 100, Ethyl Cellulose, Polyvinyl pyrrolidone, and Polyvinylacetate. The prepared formulations were uniform in their physical characteristics. The formulation F1-F4, combination of polymer (Eudragit RL 100 :EudragitRS 100) showed better performance. The results specify that aspirin transdermal patch can be designed for obtaining better therapeutic benefits.

Keywords : Aspirin; Polymers; Eudragit; Ethyl Cellulose; Polyvinyl pyrrolidone; Polyvinylacetate.