Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels, and behaves. People with schizophrenia may seem like they have lost touch with reality. Some infections have been reported among schizophrenic patients; herpes simplex is one of them. Ignored symptoms of herpes is likely to be ordinary behavior in our community, so this study aimed to follow a certain population, a schizophrenic individuals, to be checked and assessed for clinical disorder that may lead to mentally one or prevalent. This a case control study conducted to assess sero-prevalence of herpes simplex infection in Khartoum state, high frequency of antibody against HSV found in both case and control groups, they were 85.7% and 92.9% respectively . Non- specific IgG kit was used, so it recommended that a target sub-type should be assessed in coming future to indicate which type of herpes simplex more spread and it may be indicator.

Keywords : Schizophrenia. Herpes Simplex and Non-Specific.