This study aims to produce chemoentrepreneurship-oriented chemistry modules (CEP), then test the validity and practicality of the module while expressing the entrepreneurial interest of students. The type of research used is Research and Development (R&D) with a 4-D model (define, design, develop, and disseminate). The research subjects were students of class XI SMK Namira Husada Madina. The instrument used in this study was a questionnaire consisting of a questionnaire of validity and practicality that was analyzed using the Kappa Cohen formula. The results of the validity test analysis obtained kappa moment of 0.80 with a high validity category. The results of the practicality test analysis based on questionnaire responses of teachers and students obtained kappa moments respectively 0.85 ; and 0.87 with a very high category. Percentage of student’s entrepreneurial interest before carrying out learning using the CEP module was 68.9% and after learning with the CEP module the percentage of student’s entrepreneurial interest is 84.6%. Based on data analysis, the chemoentrepreneurship-oriented module developed has been valid and practically used for student learning resources as well as being able to increase the entrepreneurial interest of students in class XI Health Vocational High School.

Keywords : Modules, Entrepreneurship, Chemoentrepreneurship (CEP), Research and Development (R&D), 4-D Model.