The aims of this study is to make a valid and practical e-learning on salt hydrolysis, for grade 11th Senior High Schools (SMA/MA). This research used is Research and Development (R&D) type with ADDIE development model that have 5 stages, namely (1) analyze, (2) design, (3) development (4) implement, and evaluate. The instruments that used were interview sheets, validity sheets and practicality sheets. The data obtained were proccessing using the Formula for Cohen’s Kappa. Based the results of the content validity test, the average kappa moment was 0.87 with a very good category of validity and a construct validity test of 0.93 with a Very good category of validity. The practicality of the teacher obtained an fair rate of the kappa moment of 0.89 with the Very good practicality category, while the students have the rate of 0.80 with the category of Good practically group. From the result of this study, it can be resume that e-learning on salt hydrolysis material is valid and practical, so it can utilized in learning activities, paticullary in the study of salt hydrolysis

Keywords : Content Learning System Blended Learning, salt hydrolysis, ADDIE