This research aims to find out: (1) produce a science learning device based on high quality guided inquiry in elementary School; (2) learn the results of the learner's cognitive learning after being used guided learning devices that have been developed: (1) defining stage; (2) design phase; (3) Development stage; and (4) the deployment stage. These research instruments include: 1) Expert assessment of the developed SCIENCE-based learning devices and Associates ' observer to teacher and student activities; 2) Test problem, then analyzed by analysis of the validation test data and test results of the study. The results of the research are; (1) Science Learning device oriented inquiry guided which include: a) syllabus, b) Learning Implementation Plan (RPP), d) Student Teaching books (BAS), e) evaluation Sheet, F) Observation sheet teacher and student activity and g) Student response sheet, indicates that this learning device meets the very valid, practical, and effective criteria used; (2) Development of learning-oriented inquiry device is effectively used in science learning. Effective indicators in this study were seen from the increase in pretest-posttest learning results and the difference in the results of pretest- posttest.