Cardiovascular disease (CVD) defined as
class of diseases that involve the heart or blood vessels.
CVD is a term for several linked pathologies, commonly
defined as coronary heart disease (CHD),
cerebrovascular disease, peripheral arterial disease,
rheumatic and congenital heart diseases and venous
thromboembolism. Cardiovascular diseases are most
popular common chronic disease. The total white blood
cell count (WBC) and its subtypes, neutrophil to
lymphocyte (N/L) ratio, can be used as an indicator of
systemic inflammation. The N/L ratio has been
demonstrated to have the greatest predictive power of
death, cardiac disease and other complications.
Elevated N/L ratio is an independent predictor of long-
term inflammation can be measured by using a variety
of biochemical and hematological markers. Although
many specific biomarkers have been identified, most of
which are time consuming and expensive. Recent
evidence indicated that the ratio of sub types of blood
cells have a significant prognostic value for
cardiovascular disease. This study to evaluate
Neutrophil-Lymphocyte ratio and platelet lymphocyte
ratio among Sudanese cardiovascular disease patients.
This study included 100 CVD patients and 100 controls
without CVD. The NLR and the PLR were calculated as
the ratio of neutrophil count to lymphocyte count and as
the ratio of platelet count to lymphocyte count,
respectively. ANOVA test was used in bivariate analysis
to assess the factors affecting NLR and PLR. NLR was
significantly higher in CVD patients when compared to
controls (5.6±3.3 vs. 1.7±0.8; P= 0.000). Also CVD
patients showed significantly higher value of PLR when
compared to control group (162.3±83.2 vs. 98.4±28.1;
P= 0.000). Moreover, both parameters (NLR & PLR)
were significantly high in males CVD patients and non-
STEMI CVD subtype (P < 0.05).In this study, NLR and
PLR, simple inflammatory marker, can be used as an
auxiliary parameter for predicting the diagnosis of
CVD. And also, they can provide an additional level of
risk stratification in patients with CVD.
Keywords : Cardiovascular Disease, Platelet Lymphocyte Ratio And Neutrophil-Lymphocyte Ratio.
