The present investigation or proposal study being carried out to maximize the therapeutic effect of metronidazole tablet with respect to time, thereby, pre formulating the API, enhancing effervescent phenomena approach, incorporating the excipient guar gum, assuring its stability and compatibility parameters with the API and therefore resulting in sustained release profile of metronidazole, further masking taste of API and possessing binding property, eventually controlling programmed drug delivery rates. METHOD: The methodology involved the pre formulation or prototype formulation development thesis, evaluating the physicochemical and flow properties of ingredients and formulation stability under different circumstances. Initially excipients/ingredients were identified with the incorporation of guar gum in formulation, testing their flow properties. Secondly compatibility and stability studies were carried out via FTIR and DSC including physical appearance test, mixing proportions of excipients with API, mixture examined initially after mixing and further examined under stress conditions of temperature 40-45 degree Celsius and relative humidity of 75%. Third parameter was the evaluation of particle size by distribution via method of different mesh size (20, 25, 30, 35, 40, 70 and 100) and size calculated. Further important parameters involved bulk and tap density, compressibility index, angle of repose and hygroscopicity of excipients/powders evaluation. For effervescent phenomena approach method of mixing and granulation should be so considered to assure stability of dosage form. The purpose served by evaluating or examine the appropriate method of granulation , selecting either of the compatible methods from the two wet granulation or thermoplastic method of granulation, keeping in consideration the ingredients particularly guar gum. Furthermore, post compression evaluation conducted to assure weight variation, friability values, pH of solution, measurement of CO2 content, hardness of tablets, effervescent cessation time, thickness, assay profiles, content uniformity, water content, equilibrium moisture content of metronidazole effervescent tablets. Post formulation parameters being examined include in vitro studies evaluating calibration graph of metronidazole, dissolution time, disintegration time of effervescent formulation of metronidazole tablets incorporating guar gum as excipient for sustained release and in addition for its binding ability and taste masking ability.

Keywords : Our formulation research proposal studies expecting to be a successful approach in future, ultimately fulfilling the demand for patient satisfaction and compliance