The present investigation was aimed to determine hepatoprotective potential of ethanol leaf extract of Hugonia mystax (HMEE). 100 mg/kg silymarin and 200 and 400 mg/kg p.o HMEE were administered to the Group III to Group V respectively. Antioxidant parameters tissue glutathione (GSH) and lipid peroxidation (LPO) levels and histopathological observations are assessed. in vivo antioxidants studies and Histopathological findings established liver protection effects of HMEE.

Keywords : Hugonia mystax, Ethanol, Hepatoprotective, Antioxidant.