The burden of chronic kidney disease is increasing in alarming proportion all over the world. Hemodialysis is a well-recognized modality of treating patients having end stage renal disease. Foot reflexology serves to relax, improve circulation and promote a general feeling of wellness among hemodialysis patients. Aim: To assess the effectiveness of foot reflexology on physiological variables and anxiety among hemodialysis patients. Material & Methods: A quasi-experimental pretest posttest control group design was used. Twelve patients underwent hemodialysis were selected from four hemodialysis centers. Foot reflexology given for 2 weeks in an alternative day. Researcher used numerical pain rating scale for pain, fatigue severity scale for fatigue, sphygmomanometer for blood pressure, doppler ultrasound for blood flow and Zung anxiety self-rating scale for anxiety to collect the data

Keywords : Foot Reflexology, Physiological Variables, Anxiety, Hemodialysis.