The process of formation of stones in the kidney, bladder, and/or urethra (urinary tract) is known as Urolithiasis. According to WHO, urolithiasis covered 12 ％ of the total population and its proportion in males is 70-81% and in females 47-60% and their ratio is 2.4:1. Traditional plants had various chemical constituents which show constructive effects on lithiasis by numerous molecular mechanisms. A number of medicinal plants possessed antiurolithiatic effects include Moringa oleifera, Crataeva magna, Aerva javanica, Peperomia tetraphylla, Terminalia bellirica, Ipomoea eriocarpa, Punica granatum, Hibiscus rosasinensis, Costus spiralis, Herniaria hirsuta.. The present review is to provide the information and highlights in the present trends in research of medicinal plants with antiurolithiatic activity. This review may help to identify lead compounds or herbal products responsible for urolithiatic activity

Keywords : Urolithiasis, Molecular Mechanism, Traditional Plants, Lead Compound