The main objective of this study was to evaluate the normal range of thyroid uptake and determine the thyroid volume in patients who has normal thyroid function test (T.F.T) & homogenous distribution of the radiotracer in Sudanese especially in Radiation & Isotope Center Khartoum (RICK) & Elnelain Medical Diagnostic Center. This study includes 400 patients (85% female, 15%male) in different age, sex, center of origin and type of food and drink intake, for nine months From May 2017 to Feb 2020. The most frequency of ages distribute as (22- 26)15%,( 26-30)15% the thyroid uptake value in the gamma camera (mediso) & (simens), the result of this study showed that, the normal range of thyroid uptake is in the range between (0.4% —4.5%) & the thyroid volume is in the range of (20cm2 to 40cm2) there was a direct relationship between thyroid uptake and the thyroid volume that when the volume increase the uptake increase that shown in the following equation: y = 0.59x + 2.7 where x refers to thyroid volume and y refers to uptake in percent.