 Introduction Intermittent preventive treatment with Sulphadoxine + Pyrimethamine is a strategy to prevent malaria in pregnancy (NMCP/M.O.H (2012) when Sulphadoxine + Pyrimethamine is administered to pregnant mothers in second and third trimesters. The study identified factors affecting utilization of IPTp among mothers attending antenatal services in Kabuyanda HCVI, which remained at 70% (Isingiro district Planning Unit 2017).  Methods: A cross sectional study was done. 323 Pregnant Mothers aged between 15-49 years attending antenatal care were sampled on exit, and interviewed. The association between the outcome variable was tested using chi-square (x2) and odds ratio, P-value≤0.05 was considered significant.  Results: Pregnant mothers between (26-43 years) were almost two times more likely to go for IPTp (OR=1.7, 95%CI=1.01-2.7, P value=0.04) than younger ones, while married women were twice more likely to go for IPTp compared to pregnant mothers not married (OR=2.3, 95% CI=1.05-5.2, P value=0.03), nevertheless pregnant mothers who ever heard of IPTp services were twice more likely to go for IPTp services compared to those who had no information about the service (OR=0.5, 95%CI=0.3- 0.9, P value=0.03 and mothers who came to clinic and left without Sulphadoxine + Pyrimethamine were 3.3 times less likely to utilize services (OR=3.3, CI=1.9-5.8, P value=0.000). However, other factors like time spent and language used during service delivery were also mentioned for low utilization of IPTp services.  Conclusion: Utilization of IPTp-1, IPTp-2 and IPT-3 in Kabuyanda HCIV is low compared to National average, Age, Marital Status and Knowledge about the benefits of Sulphadoxine + Pyrimethamine as well as Missed opportunities were significant factors influencing utilization of IPT services. Time spent and language used at the clinic during service delivery also greatly influenced utilization of Intermittent Preventive Treatment of malaria during pregnancy at Health Centre. However, more studies are needed to strut the findings in Kabuyanda HCIV-Isingiro South Health District –Isingiro district.

Keywords : Antenatal, Sulphadoxine+Pyrimethamine, Malaria, Pregnancy.