Hyaluronic acid is naturally present in our human body. High amounts are present in eye secretion, skin and in joint spaces. Commercially, it is derived from bacterial fermentation or from cartilage of rooster combs. Its unique features of viscoelasticity, ability to retain water has made it an exemplary material for medical uses. It has wide range of usage from ophthalmology to orthopedics as well as in cosmetic dermatology. In dentistry and more so in periodontics, it has shown positive results in management of periodontal disease and surgical management of papillary loss. This short review elaborates and addresses the history, structure, functions and its numerous applications in medicine and dentistry.

Keywords : Hyaluronic Acid, Periodontics, Periodontal Disease, Orthopedics, Cosmetic Dermatology.