Leptin, a white adipose secreted hormone, plays a central part within the control of nourishment admissions and vitality use, whereas Leptin mutation gene effects in congenital leptin deficiency (CLD), which leads to leptin deficiency. Therefore, there is a lack of circulating leptin, resulting in extreme obesity, severe overeating, and severe metabolic abnormalities. The physiological and pathophysiological parts of leptin in weight have been explored broadly since its revelation in 1994. However, the pathophysiological aspects of leptin or leptin receptor mutations as to how it causes hepatic steatosis and severe obesity has not been well explained. Hence, this submission aims to describe leptin and outline how it is associated with congenital leptin deficiency.

Keywords : Leptin, Congenital Leptin Deficiency, Lepbr, Obesity, Exercise and Leptin Mutation.