Oral submucous fibrosis (OSMF) is a increased risk of precancerous condition characterized by alterations in the connective tissue fibers of the lamina propria and deeper parts leading to stiffness of the mucosa and restricted mouth opening. OSMF is a chronic progressive disease that affects the oral mucosa as well as the pharynx and the upper two-thirds of the esophagus. The causative factors of OSMF are areca nut chewing, ingestion of chilies, genetic factors, immunologic processes, nutritional deficiencies, and others. This study aims to discuss about the unique, case of OSMF with angular cheilitis.