Numerous literature assessments have shown that periodontitis, despite inducing local inflammation, can also cause diverse systemic effects, similarly presence of any systemic conditions such as diabetes mellitus, hypertension, hematological diseases, cardiovascular disease, respiratory disorders, endocrine disorders, etc. can individually or collectively attribute to local inflammatory reaction resulting in complete loss of teeth and its associated structures. Among these systemic factors hematological disorders are uncommon and rare disorders that demonstrate non-specific oral and periodontal manifestations. The present review was undertaken to discuss briefly on the impact and role of various hematological disorders manifesting with substantial periodontal disease.

Keywords : Anemia, Cellular infiltration, Inflammation, Leukemia, Polymorphonuclear leukocytes, Tooth loss.