Prevention is based on better control and care of central venous catheter-associated bloodstream infections by establishing a theoretical foundation with a scientific basis that contributes to nursing practice worldwide. Objective: To review the scientific evidence on the prevention of central venous catheter-associated bloodstream infections. Methodology: A bibliographic review of original articles with relevant information on prevention was carried out through the following search engines: PubMed, Scielo, Redalyc and Medigraphic, maximum of 5 years, in Spanish and English. Results: A total of 8181 were obtained, as a result of selection 20 high impact articles were included whose main variables were related to the prevention of bloodstream infections that are associated with central venous catheter. Conclusions: Associated risk factors and prevention methods were evidenced that, from nursing practice, can be applied to avoid complications, existing preventions such as the proper use of medical equipment and the respective sterilization of the instruments to be used, in addition to frequent hand washing of personnel, can avoid infections of bacteria such as coagulase staphylococcus, staphylococcus epidermidis, enterococcus, staphylococcus aureus and candida.

Keywords : Infections, Prevention, Catheter, Bacteria, Mortality