Routine use of drugs has become the integral part in the maintenance of health care of an individual. Blending of various number of drugs in a fixed ratio to the single drug form – FDC. FDC have been turned out to be beneficial when compared to single drug, in-terms of safety and effectiveness, yet some irrational combination persists. FDC’s are admissible only when the dosage of each ingredient in the mixture meets the requirements of the proposed population group and also when the combination has a proven advantage over single drug in terms of therapeutic effect & patient compliance [1]. FDCs are gaining popularity in the Indian Pharmaceutical Market and have been prospering from last decade[2]. This manuscript intends to appraise the common FDC’s prescribed in the various dental treatments and discuss the merits and demerits of FDC, irrational combinations, Indian scenario of FDC and its approvals, its controversies in general and creating awareness among dental practitioners regarding this aspect [2]

Keywords : Fixed Drug Combinations, Irrational Combinations, Compliance, Banned Drugs, Regulatory Bodies, Rational Combinations, Ingredients.