Vitamin D deficiency is associated with an increased risk of many adverse health effects. Vitamin D plays an important role in immunity and its classic effects on calcium and bone homeostasis. Enzymes that metabolize vitamin D and vitamin D receptor (VDR) are present in many cell types, including various immune cells such as antigen presenting cells, T cells, B cells, and monocytes. Vitamin D has the ability to play an autocrine role in the local immune environment. Vitamin D can regulate innate and adaptive immune responses. Vitamin D deficiency is related to decreased autoimmunity and increased susceptibility to infection. The beneficial effects of vitamin D supplementation on individuals lacking autoimmune diseases may exceed its effects on calcium and bone homeostasis. The main concern of the Unani medical system is human health, and its maintenance is the main function of Tabiat (immunity). Tabiat plays role in different stages of disease. If it exceeds time, the disease process will develop. Unani physician offers a variety of natural therapies, and regiminal therapy is one of them. The main purpose of this review article is to explore this ancient holistic pathy and establish a connection with modern theory.

Keywords : VDR, Tabiat, Autocrine, Regiminal.