The elderly population is increasing as the quality of health care improves. Globally, 50% of all elderly people are estimated to have had at least one surgical procedure and postoperative cognitive dysfunction (POCD) is one of the most common postoperative complications and is often poorly understood in the medical field. this population. Although the issue of POCD has been reported in the literature for more than a century and it remains an interest in anesthetic research today. Until now, there are no studies that can explain the specific mechanism of POCD due to old age. Surgery and anesthesia are also risk factors for POCD. Methods: This is an observational analytical study with a cross-sectional design. This study involved 61 patients who were evaluated from May to July 2021. Cognitive evaluation using the MMSE was carried out preoperatively and postoperatively. Patients with abnormal MMSE (score <24) were excluded from the study. Evaluation of delirium was performed before postoperative cognitive evaluation with CAM score, if delirium occur, the subject was excluded from the study. Risk factor data were tested bivariate. Results: In 61 patients who were evaluated from May to July 2021. There were 8 patients who were excluded from the study because 3 patients had abnormal MMSE values before surgery and 5 patients had postoperative delirium so that they were excluded. The bivariate analysis showed that the ASA score and the number of comorbidities were risk factors for the occurrence of POCD (p=0.001 and p=0.002, respectively). Conclusion: The number of comorbidities and the ASA score were significant as risk factors for postoperative cognitive dysfunction

Keywords : Postoperative Cognitive Dysfunction, Risk Factors, Elderly, MMSE.