Verneuil's disease, or hidradenitis suppurativa (HS), is a chronic inflammatory skin condition that affects apocrine glands in the axillary and anogenital regions. It is a suppurative and fistulizing disease and its degeneration into squamous cell carcinoma (SCC) is exceptional. We report a rare case of a 61-year-old man with 44 years history of Verneuil's disease confined to the perineal region. The patient was admitted to the emergency department for worsening symptoms over the last two months. Histological analysis of a skin biopsy revealed a squamous cell carcinoma treated with surgical excision. After one year of follow-up, outcome has remained favorable. He didn’t present any sign of recurrence or metastatic spread. The transformation of hidradenitis suppurativa to squamous cell carcinoma is rare and often diagnosed too late and thus at advanced stage. It is considered the most severe complication of hidradenitis suppurativa. Close monitoring of patients with HS helps finding modification or worsening of skin lesions and allows early treatment.

Keywords : Verneuil’s Disease, Hidradenitis Suppurativa, Squamous Cell Carcinoma