The past decade has seen the emergence of a new radical and ground breaking area of research known as cancer nanotechnology. Using this technology, nanoparticles are being developed in the size range of 1- 250 nm and loaded with drugs, imaging agents and genetic materials for improved chemotherapeutic action. In this work, we have developed XO infused Fricke gel dosimetry and tested the effect of radiation enhancement in the presence of AuNPs. The radiation therapy involves the use of both high energy (MV) and low energy radiation (kV). The results of this work clearly show that in the presence of AuNPs, there can be a great impact on the absorbed radiation and thereby increases the killing efficacy of the cancer cell due to radiation. The use of AuNPs in radiation enhancement and dosimetry planning using Fricke gel has not been reported in the literature. Hence, the finding of this research work is novel and has potential to change the way cancer is currently being treated.