The efforts of safety and the hazard control can be done in various ways, one of them is by using of or wearing personal protective equipment. The incident of infection at the hospital is one of the problems because it can threaten the health of the patient, medical staffs, and visitors. WHO explain that, about 2,5% of medical staff around the world facing HIV exposure, about 40% facing Hepatitis B exposure and Hepatitis C exposure and many other infection which produce from other the exposure are exist in develop country. This type of research is quantitative by correlation design. The population of this research are all of the nurse in General Hospital of Pandan about 105 persons, by sample about 39 nurses. The results of this study show that the majority of the respondents are using the personal protective equipment as many as 25 persons (64,10%), Chi Square Test was obtained p Value 0.004 (p-<0.05), it means that there is a correlation between the knowledge of the nurse with the use of personal protective equipment. Based on the Chi Square Test was obtained p Value 0.000 (p-<0.05) there is a significant relationship between the attitude of the nurse and the use of personal protective equipment. It is recommended to the all nurses to be always use the personal protective equipment in accordance with standard operational procedures as a safety and hazard control effort

Keywords : Knowledge, Attitude, Nurse, Protective Equipment.