This research aims to evaluate further the importance of Information Systems and Information Technology (IS/IT), Organizational Culture, Transformational Leadership on Organizational/Company Performance by Mediating of Work Motivation in the Inspectorate of the Cabinet Secretariat of the Republic of Indonesia. This research was included in quantitative exploratory descriptive through questionnaire to a population and a sample of 60 respondents, the sampling technique was saturated sample. The Implementation of quantitative analysis and hypothesis test was processed by SEM-PLS modeling. The estimation results from quantitative analysis were declared that 1) IS/IT affects work motivation and organizational performance with positive and significantly reaction; 2) organizational culture affects work motivation with positive and significantly reaction but has no affect to organizational performance; 3) transformational leadership affects work motivation and organizational performance with positive and significantly reaction; 4) work motivation has no affect to organizational performance; 5) IS/IT, organizational culture and transformational leadership have no affect to organizational performance through work motivation; 6) IS/IT, organizational culture and transformational leadership have a simultaneous affect both directly and indirectly to organizational performance.

Keywords : Information systems and information technology, organizational culture, transformational leadership, work motivation, organizational performance.