This research was conducted to analyze the influence of Knowledge, Attitudes and Work Motivation on Nurse Caring and the performance of nurses in the Prevention of Nosocomial Infections in the Inpatient Room of Makassar City Hospital, to analyze the effect of caring nurses on nurse performance, to analyze the influence of Knowledge, Attitudes and Work Motivation through Caring the performance of nurses in the Prevention of Nosocomial Infections in the Inpatient Room of the Makassar City Hospital. This study used a quantitative approach using primary data through a questionnaire of 200 respondents. The study was conducted in July 2019. Data were analyzed using the SEM AMOS program. The results of this study indicate that: Nurses' knowledge has a negative and significant effect on nurse caring, Nurses' attitudes have a positive and significant effect on nurse caring, Nurses' work motivation has a positive and insignificant effect on nurse caring, Nurses' knowledge has a positive and significant effect on nurse performance, Nurses' attitudes It has a negative and insignificant effect on the performance of nurses, the work motivation of nurses has a negative and significant effect on the performance of nurses, Caring of nurses has a positive and significant effect on the performance of nurses, knowledge of nurses has a negative and significant effect on performance through caring, Nurses' attitudes have a significant effect on the performance of nurses through caring. The work motivation of nurses has no significant effect on the performance of nurses through caring.

Keywords : Knowledge, Attitudes, Work Motivation, Caring, Nurse Performance.