Vaginal candidiasis is a fungal infection of the vagina. The high number of women suffer daily from vaginitis with different ages. This study was occupied to determine the incidence of Candida species isolated from vaginal candidiasis infection with the effectiveness of treatment and determined several factors related to vaginal candidiasis. Totally 250 specimen was collected from the vagina with Several predisposing factors, such as diabetes mellitus, using contraceptive, pregnancy,, broad-spectrum antibiotics, malnutrition, and kidney transplantation from different hospitals in Sana'a city, Yemen. All specimens were examined by microscope, culture and biochemical test to identify and differentiate between the Candida species. The minimum inhibitory concentration test was performed for positive cases. Of 250 samples inoculated and investigated, there were 63 /250 (25.2%) Candida species [43 (68.3%) Candida albicans, 13 ( 20.6%) Candida tropicalis, 4 ( 6.3%) Candida glabrata and 3 (4.8%) Candida kefyr].

Keywords : Vaginal Candidiasis , risk factors, Antifungal, Sana'a city , Yemen.