Primary breast lymphoma, a rare entity, accounts for a few breast malignancies. Establishing a careful histopathological diagnosis and prompt treatment planning based on multidisciplinary approach is of cardinal value. Combination chemotherapy is the mainstay of treatment as in other lymphoma, but role of radiation therapy and surgery has also been studied thoroughly. Here we discussed the clinico-pathologial features of primary non-Hodgkin lymphoma in a young female treated by R-CHOP regimen. Despite getting partial response on chemotherapy, patient was died after 1-year of initial diagnosis.

Keywords : Primary Breast Lymphoma, Non-Hodgkin Lymphoma, R-CHOP Chemotherapy, Radiation Therapy.